Best selling diet pills
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Best selling diet pills



Best selling diet pills have become increasingly popular over the years as more people look to lose weight quickly. With so many options on the market, it can be hard to know which ones are the most effective. This article will outline the best selling diet pills available today and provide an overview of how they work.

How Diet Pills Work

Best selling diet pills promote weight loss through a few main mechanisms:

  • Appetite suppression – These best selling diet pills contain ingredients designed to make you feel more full so you eat less food. Examples include hoodia, glucomannan, and green tea extract.
  • Increased fat burning – Some best selling diet pills contain stimulants like caffeine to increase your basal metabolic rate. This helps you burn more calories. Examples include green tea extract and guarana.
  • Reduced fat absorption – Ingredients like chitosan and orlistat work by blocking the absorption of fat in your digestive tract. This prevents some of the fat you eat from being stored.
  • Improved energy – Stimulants can also boost energy and exercise performance, helping you burn more calories through physical activity. Yerba mate and guarana can have this effect.

It’s important to note that no diet pills are magic bullets for weight loss. They are most effective when combined with lifestyle changes like improved diet and exercise.

Top Selling OTC Diet Pills

Here are some of the most popular over-the-counter (OTC) best selling diet pills today:

Alli/Xenical (Orlistat)

  • Best selling OTC diet pill in the US and UK [1]
  • Blocks absorption of about 25% of fat you eat [2]
  • Show modest weight loss of about 5-10 pounds on average [3]


  • One of the most popular diet pills overall, sold mainly in the US [1]
  • Contains green tea extract, caffeine, and other herbal ingredients
  • Some studies show short-term weight loss of about 10 pounds [4]


  • Marketed as a “natural” diet pill made from plant extracts
  • Contains garcinia cambogia, green coffee bean, aloe vera and other herbal ingredients
  • Claims to block fat production and suppress appetite
  • Little clinical evidence, mostly positive customer reviews [5]


  • Contains caffeine, capsicum, piperine to boost metabolism
  • Also has nopal cactus fiber as appetite suppressant
  • Said to help burn stubborn belly fat in particular [6]

Prescription Diet Pills

Prescription diet pills tend to be stronger than OTC options. They include:


  • An amphetamine-like stimulant and appetite suppressant [7]
  • Only approved for short-term use (a few weeks)
  • Average weight loss around 5% of body weight [8]


  • Activates serotonin receptors that regulate hunger [9]
  • Shows weight loss of about 5-10% in clinical trials [10]


  • Combination of bupropion (antidepressant) and naltrexone (opioid antagonist)
  • Suppresses appetite and cravings [11]
  • Trial data showed 5-10% weight loss [12]


  • Form of injectable glucagon-like peptide-1 (GLP-1) [13]
  • Reduces appetite, promotes feelings of fullness
  • Shows weight loss of 5-10%, improved glucose control [14]

Are Diet Pills Safe?

Most over-the-counter best selling diet pills are generally recognized as safe when used correctly by healthy individuals. However, some risks include:

  • Stimulant effects – Diet pills with caffeine or similar stimulants can cause insomnia, anxiety, headaches, and other effects if overused.
  • Drug interactions – Combining diet pills with other medications may change how the drugs work. This needs medical supervision.
  • Abuse potential – Stronger prescription diet pills have a higher risk of dependency and abuse.
  • Side effects – Each diet pill formulation is unique, and some cause GI issues, headaches, other reactions in some individuals.

It’s important to research and carefully follow dosage guidelines for any diet pill, and tell your doctor about any supplements you take. Short-term use under medical guidance can help minimize risks.

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The Bottom Line

When combined with lifestyle interventions, best selling diet pills may provide modest additional weight loss for some individuals. Orlistat has the most clinical support, but many popular supplements claim to burn fat and suppress appetite as well. Stronger prescription diet pills are an option under a doctor’s care. Realistic expectations, medical guidance, and common sense safety practices are recommended when trying best selling diet pills.




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